If I were involved in clinical research, I would want to take on the role of a Clinical Investigator because it connects closely with the kind of work I already do as a Quality Engineering intern In my current role,…   Read more»

That is actually a really good question, and I agree with most of the responses because it seems reasonable to think that only the patient needs to be unaware of what treatment they are receiving. The reason double blind studies…   Read more»

Clinical studies are a vital part of medical progress because they test whether years of lab research can actually improve real lives. For example, the covid 19 vaccine trials showed how research can quickly turn into life-saving solutions. Many patients…   Read more»

Unlike a good portion of the responses here, I believe the placebo effect is a reliable way to keep patients and researchers from having implicit expectations relating to the response to the given drug sample. It yields more accurate data…   Read more»

One thing I’d add is that CRAs help maintain safety and data integrity not just through monitoring, but through ongoing site training and communication. Even with ICH-GCP standards, different sites vary in experience, so CRAs make sure staff understand why…   Read more»

I think digital tools and AI are helping find eligible patients faster, but one challenge that still gets overlooked is the actual burden of participating. Even if someone wants to join, things like transportation, work schedules, childcare, or needing a…   Read more»

I feel like biomedical engineers play a more active role in clinical research rather than just a supportive one. Yes, they help design devices and analyze trial results, but they also make sure those technologies can actually work in real…   Read more»

Clinical studies are crucial in advancing medicine because they give the evidence necessary to determine whether new drugs and medical devices are effective and safe. One advantage is that they lead to discoveries that can saves lives which helps patients…   Read more»

The placebo effect can complicate clinical trials because it makes it harder to tell whether improvements in patients are because of the actual drug or the belief in the treatment. The psychological response can hide the effectiveness of a medication,…   Read more»

I think participants in pharmaceutical trials should receive compensation in some situations if it is ethical. The compensation should be based on the type of risk and time that the trial is. I think there should be a screening process…   Read more»

I think they should be given payment because it is still a risk that they are choosing to take and there are of course possible benefits of partaking in the medication, but the risks of it being harmful are far…   Read more»

I feel a standardized procedure may be hard to define as the research is quite different depending on the device that is being tested, so it can be harder to find a method that can work for everyone. However, I…   Read more»

I agree with what has been said about negative results if the placebo effect seems to be helping patients because it seems to disprove the actual use of the medication. If the placebo group were to do better in comparison…   Read more»

I really like your choice of wanting to be a Clinical Investigator. Investigators have a key responsibility in clinical research; they not only enroll and treat subjects but also make sure informed consent is obtained and that adverse events (AEs)…   Read more»

I see what you mean; it might seem like a single-blind study should be enough. However, according to this week’s notes, bias can occur not only from the patient but also from the investigator. In a double-blind study, both the…   Read more»

I agree that clinical studies are essential despite their risks. According to the Week 5 slides, clinical research is the only way to determine how a medical product, device, or drug truly works in humans, since not all results from…   Read more»

Clinical studies have many benefits, one of which is that they give researchers firsthand information on how a medication or gadget works in people. We wouldn’t have access to vaccines, life-saving therapies, or medical advancements that have enhanced global health…   Read more»

On the surface, it might appear that a single-blind research should be sufficient to minimize bias because only the patient is unaware of whether they are receiving the actual medicine or a placebo. Double-blind studies, on the other hand, are…   Read more»