I agree with gingeranderson, a company should look at how much time, effort, and cost its going to take to in-source a clinical trial. They then should call a CRO and get a quote from it and compare the two. I believe that in most cases, unless a company has some type of previous experience with clinical trials, it should hire a CRO. These companies are trained to handle clinical trials and take it from step A to Z. They’re professionals and they might even be more accredited than trying to do things yourself. This will help the process go a lot faster and that energy spent in setting up your own trials, you could invest in another project. Another thing to look at is to compare CROs and see which one is the best with respect to cost rating.