One of the largest considerations when taking a company global is meeting various international regulations. As an employee of a medical device company that has reach in Europe and Asia, much of our regulatory teams responsibility is deciphering and meeting standards set forth by the EU and individual countries. Our project manager is responsible for coordinating the efforts of our R&D and quality teams to meet the standards of other international bodies.

As far as managing a project between multiple countries, I believe that each regional PM should be able to manage and coordinate the activities of the teams that they are in charge of. Mostly because the regional PM should be aware of the cultural idiosyncrasies of the people they manage. The key, however, will be coordination and effective communication between PMs. If there are barriers to communication (language, timezones, cultural) this can cause a significant loss of efficiency and ability to complete a given project.