I believe that the only responsibility that the sponsor cannot outsource to any CRO is the overall responsibility of the clinical study. I think that any adverse events, injuries and risks will be the responsibility of the clinical study sponsor not the CRO.

As for the advantages of transferring clinical study to CROs, it mainly occurs because these organizations have huge experience in that field, plus they posses great connections and recruiting abilities which makes them capable of finding invistigators easily and effectively. They are also dedicated to monitor study results to ensure that the results are indeed reflecting the results of the study without any biased or unrealistic data.