I agree with amandaally1029 that the necessity of a clinical background depends on the role that one decides to follow. I would say that roles such as Principal Investigator in clinical research, for instance, requires a clinical background because of the nature of the tasks carried out. This is an individual charged with the responsibility of preparing, conducting, and administering a research grant in strict conformity with the relevant laws and regulations. Having a prior experience is, therefore, a necessity for a one to take up the role of a Principal Investigator. A clinical background certainly has its advantages, especially for an individual in a managerial level. While many people can work in the CRA profession without having a clinical background, for best performance, one should have a high IQ, drive, and an affinity for healthcare.