In my opinion double blind studies are more accurate as it sets a reliable baseline for the trial. As an example from the lecture would be the double blind multi-center study. In this example Dr. Simon shows that a doctor’s competence affected the study and since it was a multi-center study and double blind you can prove that the baselines were all relatively equally as bias from patient and surgeon were removed in this scenario. However, if this study were to be single blind then the surgeon bias would have to be accounted for and the statistical significance in comparing the multiple centers would decrease. Applying this same logic to the Alzheimer’s example given if any of the investigators have a financial incentive for the drug to do well, this could introduce a bias into the study that would not be present if it was conducted under double blind conditions and the investigators are not aware of the placebo vs. experimental dose.