I agree with your stand regarding clinical trials. It is necessary for discovery but comes with greater risk in the form of a negative impact on the well-being of the subject when the experiment goes awry. I think that human subjects are necessary in clinical trials however its still ways a way before we can completely eliminate this method because modeling the human body is too complex that computer simulations or animal testing are simply not enough. This is an example of the Trolley Problem where you choose between saving one life and kill more than one on another track when you pull the lever; or you let one person suffer/die for the good of the many. Clinical trials do carry this risk however I think its minimal because Human Subjects are usually towards the last phase of clinical trials where rigorous studies and experiments have been done prior to this stage.