I believe that biggest importance with handling a project proposal is to pay strong attention to the details when making the proposal. When details or omitted or forgotten they can become a way larger issue later in the projects development. For a proposal to be productive it must be easily understood by who is reading it. When developing a project, it is easier to forget details due to having a large amount of knowledge on the project. It is important to remember that whoever is reading the proposal could have zero experience with the situation. Even beyond it being understandable it is also easier to add details in earlier stages than it is in the later stages. Often once a protocol is accepted an started a CAPA is needed to make any changes at a later date.