An example of a combination product: Bone morphogenetic proteins (BMPs are a class of proteins) that induce bone formation. New technology in orthopedic repair combines BMPs with a carrier matrix to create a combination product that, when implanted in a bony defect, initiates bone formation (osteoinduction) and provides local containment and cell adhesion (osteoconduction).
Example :FDA approved INFUSE bone graft, which contains a recombinant human bone morphogenetic protein (rhBMP-2),which consists of:Recombinant human bone morphogenetic protein (rhBMP-2); absorbable collagen sponge; sterile water. Class III
Applications submitted:Separate applications submitted to CDRH and CDER: 510(k) (controller), NDA (patch)
Manufacturer: Vyteris
https://www.fda.gov/downloads/combinationproducts/meetingsconferencesworkshops/ucm116740.pdf