This year, the Right to Try act was signed into federal law. This law allows patients to request the use of investigational drugs (without FDA involvement or state law). There was a current “compassionate use” framework, but no actual law. This law allows for drugs as early as Phase I to be used. Patients may be charged the direct cost of treatment, but the company cannot make a profit.
Personally I cannot think of any negative issues with this. This law is meant for those who have a life-threatening disease/condition. At this point they would exhaust all possible options, but if there are no current solutions, they should be able to choose to try a potentially life saving drug. It may seem like there may be ethical issues with this, but I believe the current set-up for the law alleviates those worries. Hope is something that these patients deserve, and though these drugs may not save them, at least they can give them some hope.

What is your opinion on this? Feel free to add more of your own research.