There are a lot of ethical issues that arise in clinical trials. One approach that is taken to address these issues is to do a risk-benefit analysis to see if the outcome is worth the input. Medical research often requires patients or subjects to endure pain, discomfort, or even injury during procedures. Such things can lead to momentary or permanent effects, but most of the time the effects are temporary. However, there is always risk that is involved when it comes to treating patients. virtually every medication/drug has side-effects, which can vary based on the individual. Some of the medical procedures that are followed in trials are designed to carefully monitor a patient’s response to a drug treatment over a period of time. This is essential because data is required to support the argument that the treatment can be effective or can work on patients. Patients who undergo a procedure may suffer from mental stress such as anxiety, depression, or even confusion as the setting is controlled, not natural. Given these possibilities, I think that it’s permissible for patients to undergo clinical trials after they have given written consent to participate. Consent should be given after the patient is fully aware of what he/she faces during the procedure. I don’t believe that it is an attack on an individual’s freedom if he/she chooses to participate in a research project that doesn’t get approved. There are always risks and dangers when it comes to clinical trials but without participation, there’s no way to know for sure if a drug treatment is effective and should be introduced to the market. We cannot experiment on animals since their genomes are much different from humans. I think that the individual should be assessed to see if he/she is capable of making personal decisions and that a full explanation should be given beforehand to avoid legal risks and ethical issues.