As stated in previous forums and lectures in this class,, communication is the key to a large part of the product development process. In the case of the miniSim, both major delays seemed to have the best outcome, when the rational discussion between all parties involved was selected. As for your animal testing question relating to the relationship between decreasing testing time and increasing risk, I think, as with anything, there is a balance. It is key to find the balance between this in order to solve the problem successfully and move on in a timely manner with the product development.