I agree that hydrogels have many applications. I previously interned for a biotechnology company that helps patients with joint and bone diseases using a mixture Hyaluronic Acid with various proteins. The solution is a gentle hydrogel that provides a stable microenvironment to allow the body to heal itself naturally. The hydrogel can helps support cartilage and bone regeneration that can integrate within the gel, and also provides similar mechanical support as the surrounding environment. During their pre-clinical research, mechanical testing and water retention tests were very important to compare different conjugation ratios of HA/Protein mixtures. Results showed that varying the type of proteins used, and ratios of them changed the hydrogel's modulus during compression tests, and amount of water it can retain. A higher modulus with high water retention shows that such applications can be very useful as implants for patients with bone and cartilage disease.

You made some really good points about the significance of using hydrogels in pre-clinical research! Another big plus is that hydrogels can be easily modified to release drugs in a controlled manner, making them ideal for studying how treatments can be delivered effectively. Hydrogels are also known to have good biocompatibility, which means they interact well with biological tissues without causing adverse reactions. This makes them safe for in-vivo studies and helps researchers understand how materials will perform in real-world applications. 

I agree that hydrogels are the most effective tool for researchers to develop the most suitable models of drugs for clinical therapies.

Hydrogel plays a huge role in pre-clinical research due to the high volume of water content.

Due to this unique property, hydrogel helps promote regeneration, growth, and attachment of tissues and cells. Gel and liquid-like textures provide a naturally moist environment for the cells. So due to the jelly texture, it is easy to control its flow and quantity during therapies.