Budgets can be high with animal experiments. This has to do with how time and labor intensive the studies are, resources needed for animal care, long-term nature of the studies (if applicable), material and equipment costs, and compliance with regulations. Considering this, it is not worth shortening the time frame with the consequence of increasing risk. A failed study can harm the development process, with there being a need to pinpoint the source of failure, address this source of failure, and then re-do the animal experiment itself. Given the high budget of the experiment, this can prove incredibly harmful to the future outlook of the project. Of course, this is in consideration of there being no mitigation of risk in response to the shortened timeline. From my co-op experience, I have learned that studying of cells and tissues via in vitro methods prior to an animal study to solidify expected data can help mitigate risks related to animal experiments. Considering this, if faced with the need to shorten the time frame and accept the risk of failure in the animal experimental study, what methods would you use to mitigate risk? Would you do so via addressing aspects of the animal study itself (such as procedure or animal used), or would there be a more external solution?