The best time to do to do validation and verification is most naturally towards the end of a project/process. At this point, the roles and responsibilities of these tasks have been determined, meaning who will do what in what place in what capacity. More than that though, the determinations for what processes, verifications, and validations are needed have been made. This is highly important in managing the lifecycle of a product, especially in implementing small changes in response to management or regulation standards. In the design change process, determinations are made as to what validations and verifications are needed in order to implement a change. It would not make sense to perform these before the determination was made as it would create unneeded effort (validation done on aspects of device that were not even changed). For example, if a MD manufacutre wanted to add packaging sealant on the box of a MD (counts as a design change) there would be no point in doing a design verification on the MD itself as it is not changing. As such, a packaging verification/study would need to be done so as to see the impact of the changed packaging.