I agree with many have already stated-that you want to make sure you maintain the quality and integrity of the study and not focus just on the cost. However working at a hospital, I know that budget is a big part of determining if/where a clinical trial will be done. At Sloan we are located in Manhattan so as you can imagine our IDC (indirect costs) rate is very high as compared to hospital in Nebraska for example, however if we have world class physicians and an oncology focused patient population, so we have a large volume of clinical trials conducted at Sloan. We have both investigator initiated trials and sponsored trials. We also take part in a lot of multi-center trials. I agree that patient population, PIs conducting the trial, location, and cost are all important factors when contemplating a clinical trial.