One of the obvious advantages of a Placebo-Controlled Trial (PCT) is that it doesn’t require a large sample size, which also implies lower costs. This can also help the clinician determine the relevance of the clinical trials to the objective. The trade-off to working with a small sample size is that if the results of the study are valid, the conclusions regarding the treatment cannot be generalized over large population as individuals of a large group are likely to be different from each other than those of a smaller group. In contrast, studies that rely on an active control have certain advantages such as: data regarding tolerability and efficacy of the treatment can be acquired and this type of study is more likely to be approved by an ethics commission. An active-controlled study entails higher costs because the sample size is relatively large. Efficacy differences between the treatments tend to be understated or overestimated when compiling and interpreting the collected data. Moreover, subjects tend to drop out of the study due to complications and adverse effects that can take place due to treatment. Overall, I think the placebo-controlled trial is the better type of study because it’s not expensive and the sample size is small so the study is much easier to manage. The financial aspect of conducting the study is extremely important because you have to try to avoid wasting resources.