since everyone have mention about why SOP should be required during research phase, i want to add some information about SOP. SOPs should be reviewed by appropriate individuals. Reviewers could include colleagues who will be using the SOP, Quality Assurance (“QA”) managers, research facilitators, lab manager(s) or governance managers. A reviewed and revised SOP is then submitted for approval by the SOP author. Some organisations have SOP committees who approve SOPs. Sometimes it is the responsibility of one person e.g. the QA Manager or Lead Nurse.