Depending on how established the company is, GMPs may be constantly under appraisal in order to refine them. The changes can range from a minor difference in recording something to entirely modifying the system in place for the company’s QSR. Where I work, the GMPs are very well established and are rarely changed. If there is a change in the GMP, there is an extensive approval process and meetings to ensure that everyone in upper management is in agreement over the change. There are changes that can be due to technology updates as aforementioned above, but it is rarely something that would be a radical change to the system as a whole.