Executing a clinical trial can take large budgets to complete. To compete with this, companies tend to use developing countries as their regulations are less strict or even non-existent. The location of these trials makes a difference, however. For example, if it is in an area with unsafe water for consumption and the clinical trial requires water, the results could be skewed or not even be conclusive. While it does save money, companies still have to maintain all of the necessary safety measures to ensure that every subject is treated humanely.