Oxyphenbutazone is a nonsteroidal anti-inflammatory drug. It was withdrawn from markets worldwide in mid-1980 due to bone marrow suppression and Stevens-Johnson syndrome. It has been used by mouth in rheumatic disorders such as ankylosing spondylitis, osteoarthritis and rheumatoid arthritis but its use is no longer considered as there is risk of severe hematological adverse effects. Its combination with any other drug is banned in India though it is available as a single drug. Nitrofurantoin is an antibiotic used to treat bladder infection, it causes liver problems. It is banned in US but it is still sold in other countries.