My opinion applies to the business case especially coming from a family who owns and runs a business. A good project manager can run a business case based on his analytical skills and critical thinking. Before even getting to the paper work of a device, drug or any idea basically in the industry or outside, you survey the market and analyze your project idea to what is already on the market. In my opinion and experience, this is the most over looked part for start up companies in the medical industry. Many fail to exceed to compete with top companies because of this lack of knowledge and analyses on the market. This is where all the marketing, research, etc comes in. Once you survey the market, you assign team members. Keeping in mind, that just because you are motivated by an idea does not mean everyone else will put in the effort. So in my personal experience, before assigning anyone a task or placing them in your team, have a general conversation to see where that person’s interests lie. This skills and communication are essential for any start up company and ANY good project manager. If you simply just select people based on their background without having any clue to how motivated they will be for this project means you will increase your chances of doing revisions further down the line. This is simply my opinion on what is required before starting any project and selecting teams. A good project manager should have his own analysis before asking the experts to see how well he understands the project himself.