Nice article, Is innovation bad for business from a project management perspective? Yes, in my opinion, specifically discussing the implementation stage of gene therapies that cure patients of ailments is not a very financially secure idea from a project management perspective. At this particular point, it is quite possible that in order for the biotech firm to expand their portfolio of therapeutics they will lose money and the availability of test patients by the end of this endeavor. IF the company has secured a particular amount of money that will prevent severe debt or has a steady plan with a specific number of trial patients they will not exceed per year then yes. It is possible. However, at this stage, most investors will seriously weigh the pros and cons of investing in a company without longevity or stability. Now, let me say, it's not impossible, all investors are always looking for the next best medical/science innovation that will make them famous and rich but the firm will have to have enough evidence to prove that the claims they stand behind of their gene therapies cure patients of "certain" chronic ailments. Normally, clinical trials take years to be validated as well as the continued monitoring of the drug once it is put out on the market but most importantly, the available pool of treatable patients decreases with time. In my opinion, innovation is bad for business from the PM perspective. From the article you provided, historical data shows that even if these endeavors start making a profit down the road they lose money and available patients to conduct continued research on.