The "cheap" argument doesn't hold up under scrutiny: governments absorbed development costs, guaranteed markets, and funded distribution entirely, mea...

The points raised here about proactive versus reactive communication are well-taken, but I think there's an underlying issue worth naming more explici...

Partnering with a CRO doesn't eliminate risk so much as it redistributes it. You're trading execution risk for coordination risk; gaining the CRO's ex...

The points raised about timing and legal versus ethical disclosure really stand out to me as I think Dev's framing is spot on: meeting regulatory mini...

Both points about false alignment and the danger of locked-in assumptions really resonate with me. During my time at Boston Scientific, working on a d...

Building on the point about revisiting cost estimates as the project progresses, it's worth highlighting that in the medical device space specifically...

One dimension worth adding to this discussion is the role that supplier qualification and audit processes play in preventing this situation from arisi...

A technical lead telling upper management that a timeline is unrealistic will land very differently if they frame it in terms of regulatory risk, pote...

One angle that hasn't been fully explored is the idea of designating a lead PM who serves as the final decision-maker when conflicts arise, essentiall...

There's a difference between a company that rushes a product to market while deliberately concealing known safety concerns versus one that makes a cal...

Instead of only adding buffer time at the end, it can be more effective to distribute smaller buffers around high-risk or high-variability tasks, espe...

One point that stands out to me from this discussion is how critical it is to treat the initiation phase as a stage for managing uncertainty rather th...

One strategy that stands out to me is the role of organizational procedures, because they create the structure that allows the other tools, like meeti...

One aspect of EVM I find particularly valuable is its ability to improve communication between project teams and stakeholders. While several posts men...

I agree with many of the points mentioned, especially about creativity and negotiation leverage, but another possible reason could be strategic flexib...